First Stereoselective Total Synthesis of (3S,7R)-De-O-methylbotryosphaeriodiplodin:

A simple and highly efficient first stereoselective total synthesis of a benzofused macrocyclic lactone, (3S,7R)-de-O-methylbotryosphaeriodiplodin has been accomplished utilizing Jacobson's kinetic resolution, Marouka asymmetric allylation, Stille coupling, and ring-closing metathesis (RCM) reactions as key steps.