Synthesis of pyrrolidine-2,4-diones from urethane N-carboxyanhydrides (UNCAs)
1996
In the presence of a base in aprotic medium, UNCAs lead to N-urethane protected-3,5-dialkyl-3-amino pyrrolidine-2,4-diones as racemic cis/trans mixtures. Consequently the choice of the base should be carefully considered to optimize yields and avoid side products when UNCAs are used in peptide synthesis.
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