Antigen analogues as antagonists of the T cell receptor

Complexes of antigen analogues and major histocompatibitity complexes have been demonstrated to function as effective antagonists of the T cell receptor (TCR). It was observed that modification of any of the major T cell contact residues can create powerful TCR antagonists. Increasing similarity of antagonist to antigen structure resulted in increased capacity to act as a TCR antagonist up to a point beyond which the analogues themselves showed antigenicity. These data strongly suggested that peptide: TCR interaction with a certain low affinity may still be sufficient for engagement of the receptor but not for signalling, thus resulting inantagonism