Synthesis of PNA Using a Fmoc/Boc Protecting Group Strategy

Toru Sugiyama,Atsushi Kittaka,Yohei Takemoto,Reiko Kuroda

Synthesis of PNA Using a Fmoc/Boc Protecting Group Strategy

2002

Toru Sugiyama
Atsushi Kittaka
Yohei Takemoto
Reiko Kuroda

Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, we introduced 2-trimethylsilylethyI group at O6 as a second protecting group.

Keywords:

Solubility
Stereochemistry
Organic chemistry
Monomer
Chemistry
Protecting group
Nucleobase
Combinatorial chemistry

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