Protein-Protein Interaction between Glyoxalase II and Specific Redox Dependent Proteins through S-glutathionylation Modification

S-glutathionylation, the reversible formation of a mixed disulfide bridge between a specific cysteine and a glutathione molecule, can occur spontaneously or be catalyzed by enzymes. Glyoxalase II (GloII), using its natural substrate SLG can form specific protein-SSG mixed disulfide leading enzymatic regulation of S-glutathionylation.