Determination of the absolute configuration of nodulisporacid A by the concise synthesis of four stereoisomers via three-component reaction and one-pot construction of the framework

Abstract Four stereoisomers of nodulisporacid A ( 1 ) were synthesized by the concise approach which includes three-component reaction and subsequent one-pot construction of the whole framework. The 1 H NMR comparison of the derivatives ( 10 – 12 ) revealed the absolute configuration of natural 1 to be 4 R ,4′ R ,6′ R .