Optimization of femtosecond laser-constructed clear corneal wound sealability for cataract surgery.

PURPOSE To compare the sealability of femtosecond laser (FSL) corneal incisions (CIs) with that of triplanar manual (M)-CIs, and to determine FSL wound parameters minimizing leakage. SETTING Private practice. DESIGN Phase IV, single-surgeon, retrospective cohort study. METHODS One eye per patient was included. Two groups defined by the main wound (FSL-CI or M-CI) were compared with respect to leakage, inferred by placement of a suture at the end of surgery. Leakage in FSL-CIs was analyzed as a function of customizable wound parameters: anterior plane depth (APD), posterior plane depth (PPD), anterior side-cut angle (ASCA), and posterior side-cut angle (PSCA). The risk of leakage of FSL-CIs with optimal and nonoptimal parameters was further compared with that of M-CIs. RESULTS A total of 1100 eyes (757 [68.8%] FSL-CI; 343 [31.2%] M-CI) were included. Wound leakage occurred in 133 FSL-CI (17.6%) and 30 M-CI eyes (8.7%) (p < 0.001). FSL wound parameters associated with the lowest risk of leakage were: 60% APD, 70% PPD, 120° ASCA, 70° PSCA. FSL-CIs constructed with at least three optimal parameters (60% APD, 70% PPD, and 120° ASCA) had a similar risk of leakage to M-CIs (odds ratio [OR] 1.1, 95% CI [0.5, 2.3]). FSL-CIs with suboptimal parameters had twice the risk of leakage of M-CIs (OR 2.0, [1.1, 3.8]). CONCLUSIONS Overall, FSL-CIs leaked more than M-CIs. However, FSL-CIs with optimized wound profiles had an equivalent risk of leakage to M-CIs. Wound parameter customization is an asset of FSL technology that allows optimization of FSL-CI sealability.