The Role of Platelet-Activating Factor in Regional Myocardial Ischemia-Reperfusion Injury

Abstract Background . This swine model was designed to elucidate the role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. Methods . In groups 1 and 2 (n = 12 each), the left anterior descending coronary artery was ligated for 60 minutes to induce regional myocardial ischemia followed by 6 hours of reperfusion. Group 1 received the platelet-activating factor antagonist TCV-309 before ischemia, whereas group 2 did not. Group 3 (n = 3) had a sham operation. Results . Animals in group 2 exhibited significant ( p p Conclusions . These results suggest that platelet-activating factor has a definite influence on global myocardial dysfunction associated with regional myocardial ischemia-reperfusion injury.