An Informative PanelofSomatic CellHybrids forPhysical Mapping on HumanChromosome19q

Summary Apanel of22somatic cell hybrids divides the q arm ofhumanchromosome 19into 22ordered subregions. The panel wascharacterized with respect to41genetic markers. Inmostcases, asingle fragment ofchromosome 19 was presentineachhybrid. Intwocell lines the presenceofmultiple fragments ofthechromosome was demonstrated bysegregation ofthese fragments insubclones. Onthebasis oftheresults ofmarker analysis in this panel, themostlikely order ofthemarkers tested isMANB-D19S7-PEPD-D19S9-GPI-C/EBP-TGFB1