Chromosomal Translocations in B Cell Lymphomas

B cell lymphomas represent a diverse group of biologically and clinically distinct neoplasms, encompassing over 40 subtypes that derive from the malignant transformation of mature B cells, most commonly at the germinal centre (GC) stage of differentiation. Analogous to most cancer types, these tumours are caused by alterations of oncogenes and tumour suppressor genes, some of which have specific roles in GC development. This chapter will focus on the mechanisms and consequences of chromosomal translocations and other genetic lesions involved in the pathogenesis of the most common types of mature B cell lymphomas, including Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, and Burkitt Lymphoma.