Amniotic membrane for treating skin graft donor sites: A systematic review and meta-analysis

Abstract Objective To evaluate the efficacy and safety of amniotic membrane (AM) for the healing of split-thickness skin graft donor sites (STSGDS). Method Electronic search of PubMed, Cochrane library and EMBASE for randomized controlled trials (RCTs) or non-randomized clinical trials (NRCTs) of AM therapy in STSGDS. Review Manager5.3 was utilized to analyze and present the data. Results Seven studies with 219 patients were included. Compared with other treatments, the mean difference (MD) in healing time was −3.87 days (95% CI −4.39, −3.35; P   0.05); The relative risk for infection rate was 0.66 (95% CI 0.29, 2.18; I2 = 0%; P = 0.65). Conclusion This systematic review and meta-analysis indicate that it is effective and safe to use AM for treating STSGDS.