Taxane Diterpenes from Taxus baccata

Abstract From the roots of Taxus baccata, two new taxane derivatives, taxa-4(20),11-diene-10β-methoxy-2α,5α-diacetoxy-14β,α-methylbutyrate (1) and taxa-4(20-),11-diene-5α-hydroxy-1β, 7β,9α, 10β-tetraacetate (2) were obtained together with the known diterpenoids taxusin (3) 7β-acetoxytaxusin (4) and 2-deacetoxytaxinin J (5). In addition to these diterpenoids, a compound previously identified as taxa-4 (20), 11-diene, 5α,7β,10β-triacetoxy-2α,α-methylbutyrate was isolated and its structure has been revised as taxa-4(20), 11-diene-2α,5α,10β-triacetoxy-14β, α-methylbutyrate (6).