Investigation of Various Events Occurring in the Brain Tissue After Calvarial Defects in Rats Investigación de las Alteraciones Ocurridas en el Tejido Cerebral Posterior a la Creación de Defectos en la Calvaria de Ratas

th day DEXA), critical size cranial model treated with Dexamethasone (0.05 mg/kg intramuscular injection) +Synthetic graft (n= 10) One calvarium defect of 7 mm was made in the parietal bone of each animal under general ane sthesia. Calvarial defect results in dilatation of blood vessels, hemorrhage and deterioration was observed in glial fibrillary structur es. Additionally, the increase in vascular endothelial growth factor expression showed a positive reaction with glial fibrillary acid protein ast rocytes extensions. Apoptotic glial cells stained positive with Bcl-2. Calvarial defects caused by mild brain injury, to be induced by inflammatory cytokines, interrupting glial fibrillary degeneration by affecting the blood brain barrier is thought to promote apoptotic chan ges.