The role of CD25 antibody in unrelated hematopoietic stem cell transplantation

Objective To explore the role of CD_(25) antibody on engraftment and graft-versus-host disease(GVHD) prophylaxis in unrelated hematopoietic stem cell transplantation(UHSCT).Methods(CD_(25) 1 mg/kg) was given on day 1,day 4 post-transplantation in 27 patients of UHSCT.Results(Hematopoietic recovery) was obtained in 26 patients.One patient died before hematopoietic recovery.Acute GVHD occurred in 17 patients and 6 patients with Ⅱor more than degree acute GVHD(23%).Three patients experienced relapse and other 3 patients with serious infection.In these 26 eligible patients,19 patients got disease free survival.Conclusions CD_(25) antibody plays an important role on engraftment and GVHD prophylaxis in the treatment of UHSCT and does not increase rate of leukemia relapse.It provides a way of GVHD prophylaxis in unrelated and HLA mismatched hematopoietic stem cell transplantation.