Unsupervised Feature Selection via Adaptive Embedding and Sparse Learning for Parkinson’s Disease Diagnosis

Parkinson’s disease (PD) is known as a progressive neurodegenerative disease in elderly people. Apart from decelerating the disease exacerbation, early and accurate diagnosis also alleviates mental and physical sufferings and provides timely and appropriate medication. In this paper, we propose an unsupervised feature selection method via adaptive manifold embedding and sparse learning exploiting longitudinal multimodal neuroimaging data for classification and regression prediction. Specifically, the proposed method simultaneously carries out feature selection and dynamic local structure learning to obtain the structural information inherent in the neuroimaging data. We conduct extensive experiments on the publicly available Parkinson’s progression markers initiative (PPMI) dataset to validate the proposed method. Our proposed method outperforms other state-of-the-art methods in terms of classification and regression prediction performance.