New method for preparing 3-pyridine acetic hydrochloride

The new method of preparing 3-pyridyl acetic acid hydrochloride salt disclosed in the present invention, the method comprises nicotinic acid ethyl ester as starting material, the reaction with sodium metal and ethyl acetate, and then hydrolyzed to form 3-acetyl pyridine; 3-acetyl pyridine with sulfur and morpholine to produce 3-pyridylthio-acetyl morpholine; morpholin-3-pyridinyl-acetyl thio after hydrochloric acid hydrolysis, and then purified by hydrochloric acid to give pure I. Synthesis was improved, simple, significantly reduced costs, improved product quality is obviously more suitable for industrial production, which are important intermediates for the preparation of an anti-osteoporosis agent of risedronate.