Curvularin derivatives and preparation method and application thereof

The invention relates to microbe medicament technology, and specifically relates to curvularin derivatives and a preparation method and an application thereof. The curvularin derivatives have a chemical structural formula shown as formula I, wherein R1 and R2 are H or R5CO; R3 is H or R6CO; R4 is H, alkyl containing 1-20 carbon atoms or alkoxy; when R1 or R2 is R5CO, R5 is H, linear or branched alkyl containing 1-20 carbon atoms, alkenyl, phenyl, substituted phenyl, or aryl containing hetero atoms; when R3 is R6CO, R6 is H, linear or branched alkyl containing 1-20 carbon atoms, alkenyl, phenyl, substituted phenyl, or aryl containing hetero atoms. The prepared curvularin derivatives are subjected to fermentation production by using microbes, and the preparation method has the characteristics of simple operation technology, short production period and low product cost.