Bevacizumab induced bilateral renal infarction

A 62-year-old female with colon cancer and peritoneal metastasis was treated with an IV infusion of bevacizumab 5 mg/kg (the first days) combined with FOLFOX (oxaliplatin, leucovorin, 5-fluorouracil) chemotherapy, 14 days as a cycle. At the end of the 7 cycles, the patient developed waist discomfort, body temperature was 38.6 ℃. CT showed bilateral renal infarction, it was considered to be caused by bevacizumab. Bevacizumab was withdrawn and FOLFOX regimen continued. After 3 cycles of chemotherapy, the regimen changed to capecitabine monotherapy. Four months later, CT showed bilateral renal infarct size reduced. Key words: Bevacizumab; Renal artery obstruction