pharmaceutical composition comprising an agonist of 5HT1 receptor.

2002 
A pharmaceutical composition of a solid dosage form coated for oral administration and that administration disintegrates and disperses within the gastrointestinal tract, comprising sumatriptan or a pharmaceutically acceptable salt or solvate thereof as an active ingredient, wherein the amount sumatriptan, expressed as the weight of free base, is in the range of 20 mg to 150 mg; and comprising the basic component of an effervescent couple, a disintegrant and an insoluble filler, wherein the base component comprises from 5 to 50% by weight, the disintegrant comprises from 0, 5 to 10% by weight and the material insoluble filler comprises from 35 to 80% by weight, said insoluble filler transport agent comprising from 1 to 99% by weight, based on the dry weight of the dosage form; and wherein more than 70% of the active ingredient is dissolved in simulated gastric fluid (SGF) at an interval of 5 minutes in USPII apparatus at the discriminating paddle speed of 10 rpm.
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