Synthesis and Biological Evaluation of 18-Methoxycoronaridine Congeners. Potential Antiaddiction Agents

Variation of the methoxycarbonyl and C-18 substituents of the antiaddictive compound 18-methoxycoronaridine, and contraction of its isoquinuclidine ring segment, provided 15 congeners for SAR evaluation at opioid and α3β4 nicotinic acetylcholine receptors. The opioid activities were relatively low, and the α3β4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities.