Quality tests for ibuprofen preparations

: Ibuprofen preparations were tested with a view to checking their quality by physical methods such as determination, disintegration and dissolution tests. These studies were carried out on 48 kinds of commercial ibuprofen preparations. The drug content of each preparation was measured by spectrophotometry (264nm), and the values were in the range of 90-110%. In the disintegration tests of 36 tablets, a few tablets of two preparations failed to disintegrate completely after 60 minutes. However the number of such tablets was within the limit specified in JP. The dissolution test described in the USP monograph was also applied to the 36 tablets, and it was found that 9 tablets failed the test provision that over 70% of the tablets must be dissolved within 30 minutes.