ASSOCIATION OF ADIPONECTIN & T- CADHERIN WITH CARDIOVASCULAR DISEASE – A REVIEW ARTICLE -

Adipose tissue secretes adipokines like adiponectin during physiological and pathological states. Adiponectin is related with diet-induced and inflammation – induced obesity, which has secondary adverse effects on cardiovascular system. T-cadherin is the receptor of adiponectin which is expressed in the heart and blood vessels. Various Experimental studies show that T-cad is linked with adiponectin in cardiovascular tissues and is essential for adiponectin-associated cardio-protection. Recent studies and the analysis of data reflect that T-cadherin (encoded by CDH13 gene) is concern with the onset of atherosclerosis and coronary heart disease (CHD) and its development. Single nucleotide polymorphisms (SNPs) in CDH13 gene are associated with T-cadherin & adiponectin and with the levels of lipid, but their role in coronary artery disease and its development is yet to be investigated. This review suggests that the mechanism of action and the association of adiponectin and T-cadherin in relation to cardiovascular diseases (CVDs) may play a significant role to reduce the CVDs complications and associated mortality. Furthermore, studies are required to find out the association of adiponectin and T-cadherin with CVDs.