Development of research on graft-versus-host disease and graft-versus-leukemia

Allogeneic bone marrow transplantation(allo-BMT) is now an effective treatment for multiple maglinant hematological tumors.Graft-versus-leukemia(GVL) after allo-BMT can eliminate residual tumor cells and improve survivals,while it is closely related with severe graft-versus-host diseases(GVHD).Recent studies clarified the pathological changes of acute GVHD,being different from the old concepts.Now many scientists reached an agreement that although we can't separate GVHD and GVL completely,we can take some advantage of some immune cells,chemokines,cell signals,tissue antigens to reduce GVHD as well as remain GVL.