Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States

Ebola virus (EBOV) infections have caused extraordinary morbidity and mortality among persons in Guinea, Sierra Leone, and Liberia since late 2013 (1–6). More than 850 cases of Ebola virus disease (EVD) have been reported among health care personnel in western Africa (5). On 30 September 2014, the first case of EVD identified in the United States was confirmed in a Liberian man who traveled from Liberia to Dallas, Texas, on 20 September and became ill 4 days later. He was admitted to an intensive care unit (ICU) isolation room on 29 September and died on 8 October. Subsequently, 2 nurses who had cared for this patient in the ICU became ill and were diagnosed with EVD. In this article, we review the clinical and laboratory data for these 3 patients and describe the clinical course and management of the index patient and the first 2 patients with EBOV infection acquired in the United States.