Problem of enhancing the biological effect of ionizing radiation. Report 10. Radiosensitizing effect of 5-nitrotryptamine

The use of 5-nitrotryptamine (5-NT) as a radiosensitizer for hypoxic tumor cells was investigated. Mice were exposed to total-body cesium 137 gamma radiation 15 minutes after an intraperitoneal injection of 5NT. General gas hypoxia was created by pumping 6% O/sub 2/ and 94% N/sub 2/ through the chamber with the animals, in which they were exposed to radiation. The radiosensitizing effects of 5-NT were demonstrated in survival curves of mice of different strains as a function of radiation dose, hypoxia and prior administration of 5-NT.