The analyse and the result that chronic heoatitis B patient take place the variation of YMDD detectioned with PCR

Objective The analysis is that chronic hepatitis B patient take place the variation of YMDD after taking the 1 amivudine.Methods Using FQ-PCR technique examine hepatitis B virus DNA in the serum,make sure thre gene belongs to the wild type(YMDD) or mutation types(YIDD YVDD).Results There are 81 out of 191 cases having occurrence YMDD variation,of these,69 cases have been in patients with lamivudine.Conclusion The YMDD variation in sufferer who take the Lamivudine is obvious higher than did not take the Lamivudine sufferer(P＜0.01). Key words: Chronic hepatitis; Lamivudine; YMDD; Variation