The role of ACKR3 in breast, lung and brain cancer.

Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on ACKR3. This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumour cell proliferation and migration, tumour angiogenesis or resistance to drugs, thus contributing to cancer progression and metastasis occurrence. Here we focus on the clinical significance and potential mechanisms underlying the pathological role of ACKR3 in breast, lung and brain cancer and discuss its possible relevance as prognostic factor and potential therapeutic target in these contexts.