Galeterone to target proteasomal degradation of the androgen receptor in prostate tumor cells: A novel mechanism of action for treatment of AR-V7+ CRPC.

Daniel T. Dransfield,Douglas B. Jacoby,Nivedita Namdev,Andrew K. Kwegyir-Afful,Vincent C. O. Njar

Galeterone to target proteasomal degradation of the androgen receptor in prostate tumor cells: A novel mechanism of action for treatment of AR-V7+ CRPC.

2016

Daniel T. Dransfield
Douglas B. Jacoby
Nivedita Namdev
Andrew K. Kwegyir-Afful
Vincent C. O. Njar

e14092Background: Galeterone is an oral small molecule that disrupts androgen receptor (AR) signaling via multiple pathways: AR degradation, CYP17 inhibition, and AR antagonism. By enhancing ubiqui...

Keywords:

Androgen receptor
Cancer research
Galeterone
Prostate
Pathology
Mechanism of action
Medicine
Antagonism
tumor cells
Small molecule

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