Cellular activation of selected signaling proteins through resistance training—a training methodological perspective

The Akt-mTOR-p70S6k-4E-BP1 signaling pathway is a well-considered regulator of protein synthesis in the context of strength training. This process is essential for exercise-induced skeletal muscle growth. The objective of this review article was to analyze the design of acute resistance training protocols and evaluate the possible impact of different loading conditions on the activation of growth-related signaling cascades in human skeletal muscle. In all, 12 human studies were included in this review. The training intensity in the studies varied between 30% 1RM (one repetition maximum) and maximal load. The signaling proteins were measured in a time range between immediately and 24 h after training.