Design and Optimization of Curcumin–HPβCD Bioadhesive Vaginal Tablets by 23 Factorial Design: In Vitro and In Vivo Evaluation

Purpose Candida albicans is the major cause of candidiasis. Better patient compliance and therapeutic efficacy can be achieved by utilizing herbal antifungal agent curcumin which is 2.5-fold more potent than fluconazole at inhibiting the adhesion of C. albicans.