BASIC AND CLINICAL STUDIES WITH HEMATOPORPHYRIN DERIVATIVE PHOTORADIATION THERAPY (HPD-PRT)

In the three years that we have been employing HPD-PRT, 149 patients have been treated at 588 different sites. The locations of the malignancies have fallen primarily into the following anatomical regions: chest wall (breast cancer recurrences), head and neck (oral cavity, nasopharynx, vocal cords), lung, female genital (cervix, vagina, vulva), and miscellaneous areas that Included cancers such as Kaposi sarcoma, melanoma, basal cell nevus, angiosarcoma, and Merkel cell carcinoma. Seventy-two percent of all sites showed a favorable response (partial or complete response). For individual anatomical groups the percent favorable response were as follows: chest wall, 83%; head and neck, 53%; lung, 67%; genital, 67%; and miscellaneous, 32%.