TO COMPARE CLINICAL EFFICACY OF CLONIDINE AND FENTANYL AS ADJUVANT IN SUB-ARACHNOID BLOCK FOR ABDOMINAL HYSTERECTOMY .

AIM AND OBJECTIVES-The aim of this study was to assess  the onset and duration, level of sensory and  motor block, hemodynamic parameters and adverse effects of combination of clonidine and fentanyl given intrathecallywith hyperbaric 0.5% bupivacaine.MATERIAL AND METHODS: In this Prospective, double blind study 120 patients posted for TAH were randomized into fourgroups.Group  B received  (0.5% Hyperbaric Bupivacaine 3.5 ml),Group BC  received (0.5% Hyperbaric  Bupivacaine 3.0 ml +  clonidine 30 mcg with saline 0.3 ml )Group BF received (0.5% Hyperbaric  Bupivacaine 3.0 ml+ Fentanyl 15mcgs with saline 0.2 ml  )Group  BCF (0.5% Hyperbaric Bupivacaine 3.0 ml with  clonidine 30 mcg and fentanyl 15mcgs ).The onset and duration of sensory and motor block, hemodynamic parameters and the incidence of side effects in all four groups were noted and compared.RESULT-Significant prolongation of duration of sensory and motor block was found  in group BCF. Fall in mean BP and heart rate was seen in BCF group at clinically acceptable levels without significant adverse effects.CONCLUSION- Addition of  low dose clonidine and fentanyl together intrathecally prolongs motor and sensory block, compared to fentanyl or clonidine alone as adjuvant to Bupivacaine without any hemodynamic instability.