Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures

Aatif M. Husain,Jong W. Lee,Bradley J. Kolls,Lawrence J. Hirsch,Jonathan J. Halford,Puneet K Gupta,Yafa Minazad,Jennifer M. Jones,Suzette M. LaRoche,Susan T. Herman,Christa B. Swisher,Saurabh R. Sinha,Adriana Palade,Keith Dombrowski,William B. Gallentine,Cecil D. Hahn,Elizabeth Erway Gerard,Manjushri Bhapkar,Yuliya Lokhnygina,M. Brandon Westover

Randomized trial of lacosamide versus fosphenytoin for nonconvulsive seizures

2018

Objective: The optimal treatment of nonconvulsive seizures in critically ill patients is uncertain. We evaluated the comparative effectiveness of the antiseizure drugs lacosamide (LCM) and fosphenytoin (fPHT) in this population.

Keywords:

Randomized controlled trial
Lacosamide
Anesthesia
Fosphenytoin
Medicine
Confidence interval
Relative risk
Phenytoin
Population
Clinical endpoint

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