Studies on Peptides. LI. Application of the Solid Phase Synthesis for the Preparation of Pro-Analogues of LH and FSH Releasing Hormone

Solid phase synthesis was applied to prepare a number of LH-FSH-RH analogues. Each constituent amino acid residue of this hypothalamic principle was systematically replaced by Pro. Ten samples thus prepared, after partial purification, were submitted to biological assay. However, none of the inactive peptide, hopefully an inhibitor, was found in these analogues.