One kind of tylosin-producing bacteria, genetically engineered method and its application

The present invention relates to a tylosin-producing bacteria, genetic engineering and its application. By the same block mycaminose biosynthetic gene cluster for the synthesis of tylosin gene cluster organisms (including tylCVII, tylCV, tylCIII, tylCIV and tylCII) knockouts, can be obtained for the direct production of synthetic precursor of tilmicosin - Tellabs strain avermectin B (Tb) of. Tylosin-producing bacterium of the present invention can be used directly for the fermentative production of synthetic precursor tilmicosin simplified synthetic process of tilmicosin.