Anti coagulant activities of Brown Seaweed Sargassum cristaefolium Extract

Brown algae, Sargassum cristaefolium is grown abundant in Indonesia especially in South Sulawesi Province. In vitro anticoagulant effect of the extract has been shown. Therefore a study of Sargassum cristaefolium, used to inhibit blood coagulation in vivo was done. In this study, effect of flavonoid compounds from Sargassum cristaefoilum to elongate bleeding and blood clotting time and also (Prothrombin Time (PT) and Activated Thromboplastin Time (APTT) tests were carried out. Moreover, histology of mice stomach was also studied. From this study we found, that effect on bleeding time after 14 days treatment of Sargassum extract in vivo prolonged the clotting and bleeding time significantly (p < 0.05). Prothrombin time (PT) and activated partial thromboplastin time (APTT) tests on plasma confirm these research. From this study we conclude, that the flavonoid compound in Sargassum cristaefolium exhibited an anticoagulant activity.