Pharmacological studies on Glycosmis pentaphylla (corr.) whole plant

Glycosmis pentaphylla, a potential medicinal plant is a species of the family Rutaceae, which has been evaluated in folk medicine in Bangladesh for the estimation of several pharmacological activities. In the recent study ethanol extract of whole plant of Glycosmis pentaphylla was pharmacologically investigated to survey and assess the antioxidant, analgesic and antibacterial activities to afford a lead, for future new line of investigation. In scavenging assay by DPPH, a stable radical, the extract showed a significant inhibition of scavenging activity of DPPH radical in concentration dependent manner, where IC50 value of the extract was 32 µg/mL which was comparable to the IC50 value of the standard ascorbic acid, 16 µg/mL. In acetic acid- induced writhing test, the extract produced significant (p < 0.001) inhibition of writhing reflex (36.54 and 57.70% inhibition of writhing at the doses of 250 and 500 mg/kg body-weight, respectively) as compared to the standard drug diclofenac sodium which was in dose dependent manner. In antibacterial activity test performed by disc diffusion method, the extract showed activity against the bacterial strains including S. aureus, S. dysenteriae, S. paratyphi and S. Typhi at the dose of 250 µg/disc and 500µg/disc. The results suggest that the ethanol extract of G. pentaphylla could be a potential source of antioxidant, analgesic and antibacte- rial activity and demands for further pure compound isolation to identify the underlying mechanism.