Nutrients and Cellular Aging

1. Kirwood TBL. A systematic look at an old problem. Nature 2008;451:644–7. 2. Oeppen J, Vaupel JW. Broken limits to life expectancy. Science 2002;296:1029–31. 3. Kant AK. Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional and health implications. The third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 2000;72: 929–36. 6. Suh JH, Shenvi SV, Dixon BM, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 2004;101:3381–6. 7. Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-Lcarnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci USA 2002;99: 1876–81. 8. Fox CH, Mahoney MC, Ramsoomair D, et al. Magnesium deficiency in African-Americans: does it contribute to increased cardiovascular risk factors? J Natl Med Assoc 2003;95:257–62. 9. Vaquero MP. Magnesium and trace elements in the elderly: intake, status and recommendations. J Nutr Health Aging 2002;6:147–53. 10. Bell LT, Branstrator M, Roux C, et al. Chromosomal abnormalities in maternal and fetal tissues of magnesiumor zinc-deficient rats. Teratology 1975;12:221– 6. 11. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006;96:252–61. 12. Lanske B, Razzaque MS. Vitamin D and aging: old concepts and new insights. J Nutr Biochem 2007;18: 771–7(a). 13. Lanske B, Razzaque MS. Premature aging in klotho mutant mice: cause or consequence? Ageing Res Rev 2007; 6:73–9 (b). 14. Walter PB, Knutson MD, Paler-Martinez A, et al. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci USA 2002; 99:2264–9. 16. Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. J Nutr 2003;133:2543– 8. 17. Fong LY, Zhang L, Jiang Y, et al. Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. J Natl Cancer Inst 2005;97:40–50. 19. Chang WL, Chapkin RS, Lupton JR. Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation. J Nutr 1998;128:491–7. 20. Calder PC, Davis J, Yaqoob P, et al. Dietary fish oil suppresses human colon tumour growth in athymic mice. Clin Sci 1998;94:303–11. 21. Grune T, Jung T, Merker K, et al. Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease. Int J Biochem Cell Biol 2004;36:2519–30. 22. Vernace VA, Schmidt-Glenewinkel T, Figueiredo-Pereira ME. Aging and regulated protein degradation: who has the upper hand? Aging cell 2007;6:599–606. 23. Syntichaki P, Troulinaki K, Tavernarakis N. Protein synthesis is a novel determinant of aging in caenorhabditis elegans. Ann NY Acad Sci 2007;1119:289–95. 24. Masoro EJ, Katz MS, McMahan CA. Evidence for the glycation hypothesis of aging from the food-restricted rodent model. J Gerontol 1989;44:B20–2. 25. Cefalu WT, Bell-Farrow AD, Wang ZQ, et al. Caloric restriction decreases age-dependent accumulation of the glycoxidation products, N-(carboxymethyl) lysine and