Experimental immune complex glomerulonephritis: Immunofluorescent, light and electron microscopic study

Experimental immune complex glomerulonephritis induced with bovine serum albumin (BSA) or sheep serum (SS) was studied under immunofluorescent, light and electron microscope. Immunofluorescent study revealed fine and coarse granular immunofluorescent deposits along the glomerular basement membrane (GBM). Electron microscopic examination showed humps of electron-dense deposits in the spaces between the processes of the podocyte external to the GBM. Light microscopic examination showed acute proliferative glomerulonephritis. Taking human immune complex glomerulonephritis into account, the results of the present Study are of considerable significance to the further study of etiology, pathogenesis, pathological changes, clinical manifestations, prevention and treatment of glomerulonephritis. In addition, similar results were obtained by using either BSA or SS. Under ordinary conditions, it is suitable to use SS instead of BSA, because the former is easy to get and cheaper.