RESEARCH ARTICLE FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF NEBIVOLOL HYDRO CHLORIDE

Nebivolol is a β-1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure Nebivolol has half-life about 10 hrs. In hypertension the initial dose of nebivolol is 5mg once daily and maximum dose is 40mg once daily. Nebivolol is poorly soluble in water hence the basic objective of this study was to produce immediate release nebivolol tablets containing super disintegrant and solubilizer via wet granulation, to improve disintegration, dissolution and to get faster onset of action. super disintigrants used in this formulation microcrystalline cellulose, cross povidone and cross carmellose. pregelatinized starch as binder solution. tablets were subjected to physicochemical characterization such as thickness, weight uniformity, drug content, pH study, in vitro drug release, and stability studies. Tablets were found to be satisfactory when evaluated for thickness, weight uniformity, invitro drug release, drug content and disintegration time. The in vitro drug release in optimized formulation F6 was found to be 98 % in 60 min. The optimized formulation F6 also showed satisfactory pH, drug content (98.12%), disintegration time of 20 seconds and satisfactory stability.