Efficient catalytic transition-metal-free conditions for nucleophilic addition of arylacetylenes to aromatic ketones
2012
Abstract A mild, efficient, and transition-metal-free method for nucleophilic addition of arylacetylenes to diverse aromatic ketones, using catalytic amount of tetrabutylammonium chloride as a promoter and solid KOH as a base in THF, was developed to afford aromatic tertiary propargylic alcohols with high and excellent yields. Aliphatic ketones also gave satisfactory results.
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