BAPGAN: GAN-based Bone Age Progression of Femur and Phalange X-ray Images.

Convolutional Neural Networks play a key role in bone age assessment for investigating endocrinology, genetic, and growth disorders under various modalities and body regions. However, no researcher has tackled bone age progression/regression despite its valuable potential applications: bone-related disease diagnosis, clinical knowledge acquisition, and museum education. Therefore, we propose Bone Age Progression Generative Adversarial Network (BAPGAN) to progress/regress both femur/phalange X-ray images while preserving identity and realism. We exhaustively confirm the BAPGAN's clinical potential via Frechet Inception Distance, Visual Turing Test by two expert orthopedists, and t-Distributed Stochastic Neighbor Embedding.