Electron transfer from purine deoxynucleotides to deoxynucleotides deprotonated radical cations: in aqueous solution

Abstract In aqueous solution, the deprotonated radical cations of dCMP, TMP and Poly C created by SO 4 − can react with dAMP at a close to diffusion control rate constants which indicates a rapid electron transfer from dAMP to deprotonated radical cations of deoxynucleotides. Analogous reaction was found to occur between the deprotonated radical cation of dAMP, dCMP, TMP or Poly C and dGMP. The rate constants were determined to be 0.64–1.3×10 8 M −1 s −1 for electron transfer from dAMP toward deprotonated radical cations and 1.2–3.3×10 8 M −1 s −1 for the case of dGMP. Thus, the electron loss center caused by one electron oxidant or by ionizing radiation will end up at guanine in DNA.