Do oral ovulation induction agents offer benefits in women 38 to 43 years of age undergoing insemination cycles

Abstract Objective To compare the success of ovulation induction using oral agents versus gonadotropins (GTs) in women ≥38 years old. Study Design A retrospective cohort study was performed including all first to third stimulated IUI cycles conducted after the age of 38 years in a single academic fertility center between 01/2011 and 03/2018. Results A total of 1596 IUI cycles were included. 240 cycles were with clomiphene citrate (CC), 176 letrozole cycles and 1180 gonadotropin (GTs) cycles. The GTs group were older (p  Conclusions Clearly costs of oral agents are lower and they are more patient friendly than GTs, therefore oral agents should be first line for ovarian stimulation and IUI in women 38–43-years of age.