Is there association between non-steroidal anti-inflammatory drugs and contrast media-induced nephropathy? [Abstract in English]

Aims: To review the medical literature about the possibility of any association between the use of nonsteroidal anti-inflammatory drugs and an increase in the incidence of nephropathy induced by contrast. Source of data: Search for articles in the data base PubMed/Medline. Summary of the findings: The research demonstrated that there is no observational study or clinical trial that stand the association between the use of non-steroidal antiinflammatory drugs and nephropathy induced by contrast. There are only anecdotal reports in the midst of review articles, which include non-steroidal anti-inflammatory drugs as nephrotoxic drugs. Reviewing the mechanisms of kidney injury induced by the use of contrast media and the nonsteroidal anti-inflammatory drugs, there seems to be no reason to believe in a synchronism that lead to kidney damage. Conclusions: There is a lack of evidence in the indexed medical literature to support the assertion that non-steroidal anti-inflammatory drugs would be a risk factor for the development of nephropathy induced by contrast. KEY WORDS: ANTI-INFLAMMATORY AGENTS, NONSTEROIDAL; RISK FACTORS; KIDNEY DISEASES/chemically induced; CONTRAST MEDIA/adverse effects.