Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

George P. Liao,Eman M. M. Abdelraheem,Constantinos G. Neochoritis,Katarzyna Kurpiewska,Justyna Kalinowska-Tłuścik,David McGowan,Alexander Dömling

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids

2015

George P. Liao
Eman M. M. Abdelraheem
Constantinos G. Neochoritis
Katarzyna Kurpiewska
Justyna Kalinowska-Tłuścik
David McGowan
Alexander Dömling

The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12–22 membered rings.

Keywords:

Stereoisomerism
Molecule
Organic chemistry
Chemistry
Combinatorial chemistry
molecular conformation

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