Malignant with bone marrow necrosis: a case report and literature review

Objective To investigate the pathogenesis, clinical feature, laboratory examination characteristics and the prognosis of the bone marrow necrosis. Methods To analyze the clinical data of one case of diagnostic bone marrow necrosis and review the relevant literature. Results The peripheral blood examinations were as follows: the hemoglobin(HGB) level was 36g/L, platelet count was 17×109/L.The biochemistry tests showed that lactate dehydrogenase (LDH) was 1 454.9U/L and alkaline phosphatase(ALP) was 1 319.4U/L.Bone marrow necrosis was detected by bone marrow smear.Bone marrow biopsy was considered as a bone marrow metastatic carcinoma, which was prone to adenocarcinoma. Conclusion The bone marrow necrosis is mainly caused by the cancer, the serious infection and the drug.Its main performances were bone pain, fever, progressive decline in bloods cells, the LDH and ALP increasing and poor prognosis.In order to extend the lifetime of this kind of patients, the key lies in the early detection, the early diagnosis, and the early treatment of its primary diseases. Key words: Bone marrow necrosis; Cancer; Bone metastasis