MP24-18 SYSTEMATIC REVIEW AND META-ANALYSIS OF SIGNIFICANT CANCER DETECTION BY MRI-TARGETED BIOPSY COMPARED TO SYSTEMATIC BIOPSY

INTRODUCTION AND OBJECTIVES:MRI-targeted biopsy (MRI-TB) is a diagnostic test strategy that serves as an alternative to systematic prostate biopsy.This systematic review aimed to assess the detection rates of clinically significant (CSC) and clinically insignificant cancer (CIC) by MRI-targeted biopsy compared to systematic biopsy in men with suspected prostate cancer.METHODS:A literature search was carried out using Embase, PubMed, Web of Science, Cochrane library and Clinicaltrials.gov databases using search terms including: “biopsy”, “MRI” and “prostate” and variations of these. For inclusion, each paper needed to specify cancer detection rates from the biopsies taken only from MRI suspicious areas. Systematic biopsy included 10 to 12 core ultrasound guided transrectal (TRUS) or transperineal template mapping (TPM) biopsy. The methodological quality of included studies was assessed using a modified QUADAS-2 checklist. CSC was defined as Gleason score 3+4 or greater and CIC as Gleason score 3+3, unless ...