The absorption behavior of chemotherapeutics after intrauterine administration in cattle

: The uterus of cattle is an organ of excellent absorptive properties, as has been demonstrated by the examples of a sulphonamide and of penicillin. This is true for all cyclic phases. Absorption was somewhat delayed, when animals were in di-oestrus or pro-oestrus. A comparison between rates of absorption by clinically intact and pathomorphologically altered uteri showed absorption of Solupront and Ursopen 40,000 to be much faster in cases of disease. Experimental results as well as knowledge so far obtained on protein binding capacity are likely to support the conclusion that in the pathologically altered uterus bacteriostatic effects of sulphonamides are low due to the high amount of p-aminobenzoic acid which is present as a direct antagonist in pus and cellular detritus.