Targeting müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity

Yanchao Jiang,Haibo Wang,David Culp,Zhihong Yang,Lori Fotheringham,John G. Flannery,Scott M. Hammond,Tal Kafri,M. Elizabeth Hartnett

Targeting müller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity

2014

Yanchao Jiang
Haibo Wang
David Culp
Zhihong Yang
Lori Fotheringham
John G. Flannery
Scott M. Hammond
Tal Kafri
M. Elizabeth Hartnett

Purpose. To determine whether knockdown of Muller cell–derived VEGFA-splice variant, VEGF164, which is upregulated in the rat retinopathy of prematurity (ROP) model, safely inhibits intravitreal neovascularization (IVNV).

Keywords:

Cell
Gene knockdown
Gene Knockdown Techniques
Vascular endothelial growth factor A
Retinopathy of prematurity
Vascular endothelial growth factor
Anatomy
Neovascularization
Downregulation and upregulation
Biology

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